… matrix composition, and angiogenesis in tumors. Hence, we hypothesized that Akt1 may
be necessary for other angiogenesis-dependent processes, including wound healing. Using …

… Akt1 is the predominant isoform in vascular cells and describe the unexpected consequences
of Akt1 knockout on vascular … As cell migration is an essential step in angiogenic response, …

… of increased angiogenesis in the Akt1 −/− mice: changes in vascular permeability; a thinner
… a partial recovery. As eNOS has been shown to be necessary for blood vessel maturation, 68 …

… of vascular endothelial growth factor (VEGF) protein in chronic … important to note that the
reduction in phosphorylated Akt in … of keratinocyte angiogenic potential in wound healing. As a …

… during embryonic blood vessel formation is required for … did promote vascular network
maturation, when coadministered with … showing that, during embryonic development, Ang1 plays a …

… approach for targeting angiogenesis, which could be important for the development of new
… AKT1 is the predominant isoform in vascular cells. Recently, impaired vascular maturation …

… postnatal Akt1 deletion confers significant retinal vascular … that Akt1 is the predominant
Akt isoform in ECs necessary for … vascular development was also assessed in global Akt1-null …

… crucial mediators of vascular development, considerable progress … of angiogenesis at sites
of tissue growth and/or repair. A … attachment is required for growth factors to activate Akt and …

… of a complex vascular network required for embryonic development. Vasculogenesis can …
VEGFR phosphorylation triggers PI3K activation and phosphorylation of Akt. Active Akt blocks …

… Akt site, S 1176 , is critical for many of the vascular actions of … Our results in wound healing
and limb ischemia point toward … the predominant Akt substrate necessary for angiogenesis; …